Location: Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS
We have an exciting opportunity to join the Institute as a Research Facility Scientist within the MRC WIMM Genome Engineering, Transgenics and Virus Production Facility.
The Facility is a core service with expertise in establishing genetically modified model systems. We employ a broad range of molecular biology techniques alongside CRISPR-based genome editing technologies to produce validated, ready-to-use reagents, including genetically modified mouse models and engineered cell lines, in support of cutting-edge biomedical research.
About the role
As Research Facility Scientist, you will contribute to all aspects of model generation and validation. Responsibilities will include:
Design and construction of molecular reagents and targeting constructs
Mammalian cell culture and genome editing
Molecular genetic validation of edited lines
Embryo manipulation and transgenic model production
Cryopreservation (embryo and sperm freezing)
Rederivation of mouse lines via IVF and embryo transfer
Management of mouse colonies
You will work closely with researchers across the Institute to deliver high-quality, reproducible model systems that underpin innovative scientific programmes.
About you
You will hold a degree in Biological Sciences (or a closely related discipline) and have relevant laboratory experience. Essential experience required includes:
Molecular biology techniques
CRISPR genome editing
Mammalian cell culture
Transgenic model generation
Mouse colony management
Cryopreservation and rederivation techniques
You will also demonstrate excellent interpersonal and communication skills, strong organisational ability, and a clear commitment to supporting high-quality scientific research.
Contract type
This is a full-time (37.5 hours per week) fixed-term position for 3 years.
Application process
Applications for this vacancy are to be made online. You will be required to upload a CV and a supporting statement explaining why you consider yourself particularly suited to this position, with reference to the essentials of the person specification.
The closing date for applications is 12.00 noon on Monday 16 March 2026. Only applications received before this time can be considered. Interviews will be held on Thursday 26 March 2026.